業績・論文

201220112010200920082007200620052004200320022001

ページTOPへ

2012年 原著論文

  1. Kobayashi M., Hashimoto F., Ohe K., Nadamura T., Nishi K., Shikano N., Nishii R., Higashi T., Okazawa H. and Kawai K.
    Transport Mechanism of 11C-labeled L- and D-Methionine in Human-derived Tumor Cells.
    Nucl. Med. Biol., 39(8): 1213-1218, 2012.
  2. Arakawa H., Nakanishi T., Yanagihara C., Nishimoto T., Wakayama T., Mizokami A., Kawai K. and Tamai I.
    Enhanced Expression of Organic Anion Transporting Polypeptides (OATPs) in Androgen Receptor-positive Prostate Cancer Cells: Possible Role of OATP1A2 in Adaptive Cell Growth under Androgen-depleted Conditions.
    Biochem. Pharmacol., 84(8): 1070-1077, 2012.
  3. Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E.T. and Namiki M.
    Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer.
    Prostate, 72(16): 1789-1801, 2012.
  4. Fujita K., Sugiyama M., Akiyama Y., Hioki K., Kunishima M., Nishi K., Kobayashi M., Kawai K. and Sasaki Y.
    N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19.
    Drug Metab. Dispos., 40(5): 843-846, 2012.
  5. Kobayashi M., Mori T., Kiyono Y., Tsujikawa T., Maruyama R., Higaki Y., Shikano N., Nishii R., Kawai K., Kudo T. and Okazawa H.
    Appropriate Parameters of Ordered-Subset Expectation Maximization Algorithm on Measurement of Myocardial Blood Flow and Oxygen Consumption with 11C-Acetate PET.
    Nucl. Med. Commun., 33(2): 130-138, 2012.
  6. Kuroiwa Y., Nagamachi S., Miyati T., Yamaguchi K., Nishii R., Kuga N., Azuma T., Arita H., Maeda M., Tamura S. and Kawai K.
    The Agreement of Left Ventricular Function Parameters between 99mTc-Tetrofosmin Gated Myocardial SPECT and Gated Myocardial MRI.
    Ann. Nucl. Med., 26(2): 147-163, 2012.
  7. Kobayashi M., Mori T., Kiyono Y., Tiwari V., Maruyama R., Kawai K. and Okazawa H.
    Cerebral Oxygen Metabolism of Rats using Injectable 15O-Oxygen with a Steady-state Method.
    J. Cereb. Blood Flow Metab., 32(1): 33-40, 2012.

2012年 総説等

  1. 川井恵一
    PET薬剤と合成装置の進歩「腫瘍イメージング剤:アミノ酸PET薬剤」
    PETジャーナル, 19: 26-28, 2012.

201220112010200920082007200620052004200320022001

ページTOPへ

2011年 著書

  1. 川井恵一,他8名 共著
    放射線技術学シリーズ「放射線安全管理学」(改訂2版),日本放射線技術学会監修
    第5章 5・4. 非密封放射性同位元素の使用施設  pp.80-93,全240頁,オーム社,東京,2011.
  2. 川井恵一,他16名 共著
    「新放射化学・放射性医薬品学」(改訂第3版),佐治英郎・前田 稔・小島周二編集
    第6章 5. オートラジオグラフィー pp.102-107,第10章  6. 放射性医薬品による被ばくと管理pp.283-290,全321頁,南江堂,東京,2011.
  3. 川井恵一
    「放射線関係法規概説 −医療分野も含めて−」(第4版)
    全編 pp.1-205,全205頁,通商産業研究社,東京,2011.

2011年 原著論文

  1. Nakanishi T., Fukushi A., Sato M., Yoshifuji M., Gose T., Shirasaka Y., Ohe K., Kobayashi M., Kawai K. and Tamai I.
    Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture.
    Mol. Pharm., 8(6): 2142-2150, 2011.
  2. Kuroiwa Y., Yamashita A., Miyati T., Furukoji E., Takahashi M., Azuma T., Sugimura H., Asanuma T., Tamura S., Kawai K. and Asada Y.
    MR Signal Change in Venous Thrombus Relates Organizing Process and Thrombolytic Response in Rabbit.
    Magn. Reson. Imaging, 29(7): 975-984, 2011.
  3. Tsujikawa T., Tsuchida T., Imamura Y., Kobayashi M., Asahi S., Shimizu K., Tsuji K., Okazawa H. and Kimura H.
    Kikuchi-Fujimoto Disease: PET/CT Assessment of a Rare Cause of Cervical Lymphadenopathy.
    Clin. Nucl. Med., 36(8): 661-664, 2011.
  4. Martinez M.E., Kiyono Y., Noriki S., Inai K., Mandap K.S., Kobayashi M., Mori T., Tokunaga Y., Tiwari V.N., Okazawa H., Fujibayashi Y. and Ido T.
    New Radiosynthesis of 2-Deoxy-2-[18F]fluoroacetamido-D-glucopyranose and Its Evaluation as a Bacterial Infections Imaging Agent.
    Nucl. Med. Biol., 38(6): 807-817, 2011.
  5. Nagamachi S., Wakamatsu H., Kiyohara S., Nishii R., Mizutani Y., Fujita S., Futami S., Arita H., Kuroki M., Nakada H., Uchino N., Tamura S. and Kawai K.
    Comparison of Diagnostic and Prognostic Capabilities of 18F-FDG PET/CT, 131I-scintigraphy, and Diffusion-weighted Magnetic Resonance Imaging for Postoperative Thyroid Cancer.
    Jpn. J. Radiol., 29(6): 413-422, 2011.
  6. Okudaira H., Shikano N., Nishii R., Miyagi T., Yoshimoto M., Kobayashi M., Ohe K., Nakanishi T., Tamai I., Namiki M. and Kawai K.
    Putative Transport Mechanism and Intracellular Fate of Anti-18F-FACBC (Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid) in Human Prostate Cancer.
    J. Nucl. Med., 52(5): 822-829, 2011.
  7. Kobayashi M., Kiyono Y., Maruyama R., Mori T., Kawai K. and Okazawa H.
    Development of an H215O Steady-state Method Combining a Bolus and Slow Increasing Injection with a Multiprogramming Syringe Pump.
    J. Cereb. Blood Flow Metab., 31(2): 527-534, 2011.
  8. Ebihara K., Ishida Y., Takeda R., Abe H., Matsuo H., Kawai K., Magata Y. and Nishimori T.
    Differential Expression of FosB, c-Fos, and Zif268 in Forebrain Regions after Acute or Chronic L-DOPA Treatment in a Rat Model of Parkinson's Disease.
    Neurosci. Lett., 496(2): 90-94, 2011.
  9. Oyama N., Hasegawa Y., Kiyono Y., Kobayashi M., Fujibayashi Y., Ponde D.E., Dence C., Welch M.J. and Yokoyama O.
    Early Response Assessment in Prostate Carcinoma by 18F-Fluorothymidine Following Anticancer Therapy with Docetaxel using Preclinical Tumour Models.
    Eur. J. Nucl. Med. Mol. Imaging, 38(1): 81-89, 2011.

2011年 総説等

  1. 川井恵一
    分子イメージング薬剤の標的選択的動態制御「低分子医薬品の体内動態制御」
    Drug Delivery System, 26(4): 373-385, 2011.
  2. 川井恵一
    放射性医薬品の体内動態制御とターゲティングコンファーマティヴ個別化医療
    日本放射線技術学会雑誌, 66(3): 249-259, 2011.

201220112010200920082007200620052004200320022001

ページTOPへ

2010年 著書

  1. 川井恵一,他175名 共著
    「医用画像ハンドブック」,石田隆行・桂川茂彦・藤田広志監修
    第5編 核医学画像 第2章 核医学画像の基礎 2.2 放射性医薬品 pp.964-978,全1571頁,オーム社,東京,2010.

2010年 原著論文

  1. Taguchi K., Urata Y., Anraku M., Watanabe H., Kawai K., Komatsu T., Tsuchida E., Maruyama T. and Otagiri M.
    Superior Plasma Retention of A Cross-linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander.
    Drug Metab. Dispos., 38(12): 2124-2129, 2010.
  2. Shikano N., Kotani T., Nakajima S., Ogura M., Nakazawa S., Sagara J., Kobayashi M., Baba T., Yamaguchi N., Kubota N. and Kawai K.
    Radioiodinated 4-Iodo-L-meta-tyrosine, a System L Selective Artificial Amino Acid: Molecular Design and Transport Characterizationin in Chinese Hamster Ovary Cells (CHO-K1 Cells).
    Nucl. Med. Biol., 37(8): 903-910, 2010.
  3. Tokunaga J., Matsuo Y., Takamura N., Ogata K., Yoshida H., Nagata M., Kishimoto S., Fukushima S., Ikeda O., Nishio T., Kawai K. and Arimori K.
    Inhibition of Cisplatin Protein Binding: a Possible Therapeutic Advantage.
    J. Appl. Therapeutic Res., 7(4): 127-132, 2010.
  4. Yoshida H., Takamura N., Shuto T., Ogata K., Tokunaga J., Kawai K. and Kai H.
    The Citrus Flavonoids Hesperetin and Naringenin Block the Lipolytic Actions of TNF-α in Mouse Adipocytes.
    Biochem. Biophys. Res. Commun., 394(3): 728-732, 2010.
  5. Tokunaga J., Takamura N., Ogata K., Yoshida H., Setoguchi N., Kondo T., Nishio T. and Kawai K.
    Basic Study on Flurbiprofen Protein Binding Inhibition by an Albumin Site II Binding Inhibitor, 6-Methoxy-2-naphthyl Acetic Acid.
    J. Kyushu Univ. Health Welfare, 11: 153-158, 2010.
  6. Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Arita H., Tamura S. and Kawai K.
    The Reproducibility of Deep-inspiration Breath-hold 18F-FDG PET/CT Technique in Diagnosing Various Cancers Affected by Respiratory Motion.
    Ann. Nucl. Med., 24(3): 171-178, 2010.
  7. Shikano N., Ogura M., Okudaira H., Nakajima S., Kotani T., Kobayashi M., Nakazawa S., Baba T., Yamaguchi N., Kubota N., Iwamura Y. and Kawai K.
    Uptake of 3-[125I]Iodo-α-methyl-L-tyrosine into Colon Cancer DLD-1 Cells: Characterization and Inhibitory Effect of Natural Amino Acids and Amino Acid-like Drugs.
    Nucl. Med. Biol., 37(2): 197-204, 2010.
  8. Shikano N., Ogura M., Sagara J., Nakajima S., Kobayashi M., Baba T., Yamaguchi N., Iwamura Y., Kubota N. and Kawai K.
    Stimulation of 125I-3-Iodo-α-methyl-L-tyrosine Uptake in Chinese Hamster Ovary (CHO-K1) Cells by Tyrosine Esters.
    Nucl. Med. Biol., 37(2): 189-196, 2010.
  9. KuroiwaY., Yamashita A., Miyati T., Furukoji E., Takahashi M., Azuma T., Sugimura H., Tamura S., Kawai K. and Asada Y.
    Atherosclerotic Lesions Rich in Macrophages or Smooth Muscle Cells Discriminated in Rabbit Iliac Arteries Based on T1 Relaxation Time and Lipid Content.
    Acad. Radiol., 17(2): 230-238, 2010.
  10. Kobayashi M., Shikano N., Nishii R., Kiyono Y., Araki H., Nishi K., Oh M., Okudaira H., Ogura M., Yoshimoto M., Okazawa H., Fujibayashi Y. and Kawai K.
    Comparison of the Transcellular Transport of FDG and D-Glucose by the Kidney Epithelial Cell Line LLC-PK1.
    Nucl. Med. Commun., 31(2): 141-146, 2010.
  11. 小林正和,杉本勝也,丸山力哉,辻川哲也,工藤 崇,清野 泰,小野口昌久,川井恵一,藤林靖久,岡沢秀彦.
    18F-FDGを用いた脳PET検査の健常者データベースにおけるTransmission撮像および減弱補正法の影響.
    日本放射線技術学会雑誌, 60(1): 42-48, 2010.
  12. Tiwari V.N., Kiyono Y., Kobayashi M., Mori T., Kudo T., Okazawa H. and Fujibayashi Y.
    Automatic Labeling Method for Injectable 15O-Oxygen using Hemoglobin-containing Liposome Vesicles and Its Application for Measurement of Brain Oxygen Consumption by PET.
    Nucl. Med. Biol., 37(1): 77-83, 2010.

2010年 総説等

  1. 川井恵一
    放射性医薬品の体内動態制御と核医学イメージングの個別化医療への応用
    日本放射線技術学会核医学分科会誌, 61(2): 22-37, 2010.

201220112010200920082007200620052004200320022001

ページTOPへ

2009年 著書

  1. 川井恵一
    「放射線関係法規概説 −医療分野も含めて−」(第3版)
    全編 pp.1-205,全205頁,通商産業研究社,東京,2009.

2009年 原著論文

  1. Ogawa K., Shiba K., Akhter N., YoshimotoM., Washiyama K., Kinuya S., Kawai K. and Mori H.
    Evaluation of Radioiodinated Vesamicol Analogs for Sigma Receptor Imaging in Tumor and Radionuclide Receptor Therapy.
    Cancer Sci., 100(11): 2188-2192, 2009.
  2. Tsujikawa T., Yoshida Y., Kudo T., Kiyono Y., Kurokawa T., Kobayashi M., Tsuchida T., Fujibayashi Y., Kotsuji F. and Okazawa H.
    Functional Images Reflect Aggressiveness of Endometrial Carcinoma: Estrogen Receptor Expression Combined with FDG-PET.
    J. Nucl. Med., 50(10): 1598-1604, 2009.
  3. Uehara T., Nakagawa M., Takai N., Koike S., Furusawa Y., Ando K., Kawai K., Akizawa H., Irie T. and Arano Y.
    Intracellular Reactions Affecting 2-Amino-4-([11C]methylthio)butyric acid ([11C]Methionine) Response to Carbon Ion Radiotherapy in C10 Glioma Cells.
    Nucl. Med. Biol., 36(8): 985-991, 2009.
  4. Hussain R., Kudo T., Tsujikawa T., Kobayashi M., Fujibayashi Y. and Okazawa H.
    Validation of the Calculation of the Clearance Rate Constant (kmono) of [11C]Acetate using Parametric kmonoImage for Myocardial Oxidative Metabolism.
    Nucl. Med. Biol., 36(8): 877-882, 2009.
  5. Kuga N., Shikano N., Takamura N., Nishii R., Yamasaki K., Kobayashi M., Nagamachi S., Tamura S. and Kawai K.
    Competitive Displacement of Serum Protein Binding of Radiopharmaceuticals with Amino Acid Infusion Investigated with N-Isopropyl-p-123I-iodoamphetamine.
    J. Nucl. Med., 50(8): 1378-1383, 2009.
  6. Hussain R., Tsuchida T., Kudo T., Kobayashi M., Tsujikawa T., Kiyono Y., Fujibayashi Y. and Okazawa H.
    Vasodilatory Effect of Adenosine Triphosphate Dose not Change Cerebral Blood Flow: A PET Study with 15O-Water.
    Ann. Nucl. Med., 23(8): 717-723, 2009.
  7. Yoshii Y., Furukawa T., Yoshii H., Mori T., Kiyono Y., Waki A., Kobayashi M., Tsujikawa T., Kudo T., Okazawa H., Yonekura Y. and Fujibayashi Y.
    Cytosolic Acetyl-CoA Synthetase Affected Tumor Cell Survival under Hypoxia: The Possible Function in Tumor Acetyl-CoA/acetate Metabolism.
    Cancer Sci., 100(5): 821-827, 2009.
  8. Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Arita H., Nishii R., Tamura S. and Kawai K.
    Usefulness of a Deep-inspiration Breath-hold 18F-FDG PET/CT Technique in Diagnosing Liver, Bile Duct, and Pancreas Tumors.
    Nucl. Med. Commun., 30(5): 326-332, 2009.
  9. Oh M., Tanaka T., Kobayashi M., Furukawa T., Mori T., Fujieda S. and Fujibayashi Y.
    Radio-cooper Labeled Cu-ATSM: An Indicator of Quiescent but Clonogenic Tumor Cells under Mild Hypoxia.
    Nucl. Med. Biol., 36(4): 419-426, 2009.
  10. Mandap K.S., Ido T., Kiyono Y., Kobayashi M., Lohith T.G., Mori T., Kasamatsu S., Kudo T., Okazawa H. and Fujibayashi Y.
    Development of Microwave-based Automated Nucleophilic [18F]Fluorination System and Its Application for the Production of [18F]Flumazenil.
    Nucl. Med. Biol., 36(4): 403-409, 2009.
  11. Iwao Y., Hiraike M., Kragh-Hansen U., Kawai K., Suenaga A., Maruyama T. and Otagiri M.
    Altered Chain-length and Glycosylation Modify the Pharmacokinetics of Human Serum Albumin.
    Biochim. Biophys. Acta, 1794(4): 634-641, 2009.
  12. Mori T., Sun L.Q., Kobayashi M., Kiyono Y., Okazawa H., Furukawa T., Kawashima H., Welch M.J. and Fujibayashi Y.
    Preparation and Evaluation of Ethyl [18F]Fluoroacetate as a Pro-radiotracer of [18F]Fluoroacetate for the Measurement of Glial Metabolism by PET.
    Nucl. Med. Biol., 36(2): 155-162, 2009.
  13. Ogawa K., Mukai T., Kawai K., Takamura N., Hanaoka H., Hashimoto K., Shiba K., Mori H. and Saji H.
    Usefulness of Competitive Inhibitors of Protein Binding for Improving the Pharmacokinetics of 186Re-MAG3-conjugated Bisphosphonate (186Re-MAG3-HBP), an Agent for Treatment of Painful Bone Metastases.
    Eur. J. Nucl. Med. Mol. Imaging, 36(1): 115-121, 2009.
  14. Kawai K., Nishii R., Shikano N., Makino N., Kuga N., Yoshimoto M., Jinnouchi S., Nagamachi S., Tamura S. and Takamura N.
    Serum Protein Binding Displacement: Theoretical Analysis using a Hypothetical Radiopharmaceutical and Experimental Analysis with 123I-N-Isopropyl-p-iodoamphetamine.
    Nucl. Med. Biol., 36(1): 99-106, 2009.

201220112010200920082007200620052004200320022001

ページTOPへ

2008年 著書

  1. 川井恵一,他66名 共著
    「核医学技術総論」,日本核医学技術学会編
    第1部第2章 放射線生物学 pp.12-22,全633頁,山代印刷,京都,2008.
  2. 飯田博美,安東  醇,川井恵一
    放射線双書「放射線安全管理学」(改々題第1版)
    全編pp.1-207,全207頁,通商産業研究社,東京,2008.

2008年 原著論文

  1. Ishida Y., Kawai K., Magata Y., Ebihara K., Takeda R., Abe H., Yoshimoto M., Hashiguchi H., Odagiri K., Matsuo H. and Nishimori T.
    Differential Expression of Fos and Zif268 in the Nigrostriatal System after Methamphetamine Administration in a Rat Model of Parkinson's Disease.
    Synapse, 62(12): 920-926, 2008.
  2. NishioT., Takamura N., Nishii R., Tokunaga J., YoshimotoM. and Kawai K.
    Influence of Haemodialysis on the Binding Sites of Human Serum Albumin; Possibility of an Efficacious Administration Plan using Binding Inhibition.
    Nephrol. Dial. Transplant., 23(7): 2304-2310, 2008.
  3. Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Tamura S., Nakazato M., Yamashita S., Arita H., Nishii R. and Kawai K.
    Usefulness of rCBF Analysis in Diagnosing Parkinson's Disease: Supplemental Role with MIBG Myocardial Scintigraphy.
    Ann. Nucl. Med., 22(7): 557-564, 2008.
  4. Wakamatsu H., Nagamachi S., Nishii R., Higaki K., Kawai K., Kamimura K., Fujita S., Futami S. and Tamura S.
    Effect of Percutaneous Endoscopic Gastrostomy on Gastrointestinal Motility: Evaluation by Gastric-emptying Scintigraphy.
    Nucl. Med. Commun., 29(6): 562-567, 2008.
  5. Yoshimoto M., Ogawa K., Washiyama K., Shikano N., Mori H., Amano R. and Kawai K.
    αvβ3 Integrin-targeting Radionuclide Therapy and Imaging with Monomeric RGD Peptide.
    Int. J. Cancer, 123(3): 709-715, 2008.
  6. Nagamachi S., Wakamatsu H., Fujita S., Nishii R., Kamimura K., Kiyohara S., Futami S., Onitsuka H., Nagoshi Y., Tamura S., Kawai K. and Arita H.
    Assessment of Diastolic Function using 16-frame 201Tl Gated Myocardial Perfusion SPECT: A Comparative Study of QGS2 and pFAST2.
    Ann. Nucl. Med., 22(2): 115-122, 2008.
  7. Ogata K., Takamura N., Tokunaga J., Kawai K., Arimori K. and Higuchi S.
    Dosage Plan of Flurbiprofen Injection Product using Inhibition of Protein Binding by Lipid Emulsion in Rats.
    J. Pharm. Pharmacol., 60(1): 15-20, 2008.

201220112010200920082007200620052004200320022001

ページTOPへ

2007年 著書

  1. 河村正一,井上  修,荒野  泰,川井恵一
    放射線双書「放射化学と放射線化学」(三訂版)
    第11章 標識化合物のトレーサ利用 pp.165-180,全255頁,通商産業研究社,東京,2007.
  2. 川井恵一
    「放射線関係法規概説 −医療分野も含めて−」(第2版)
    全編 pp.1-205,全205頁,通商産業研究社,東京,2007.

2007年 原著論文

  1. Nakajima S., Shikano N., Kotani T., Ogura M., Nishii R., Yoshimoto M., Yamaguchi N., Iwamura Y., Kubota N., Ishikawa N. and Kawai K.
    Pharmacokinetics of 3-[125I]Iodo-α-methyl-L-tyrosine, a Tumor Imaging Agent, after Probenecid Loading in Mice Implanted with Colon Cancer DLD-1 Cells.
    Nucl. Med. Biol., 34(8): 1003-1008, 2007.
  2. Iwao Y., Hiraike M., Kragh-Hansen U., Mera K., Noguchi T., Anraku M., Kawai K., Maruyama T. and Otagiri M.
    Changes of Net Charge and Alpha-helical Content Affect the Pharmacokinetic Properties of Human Serum Albumin.
    Biochim. Biophys. Acta, 1774(12): 1582-1590, 2007.
  3. Shikano N., Kotani T., Nakajima S., Ogura M., Hyodo K., Sugiyama H., Monma M., Kawai K., Takeda T., Kubota N., Nishimura K., Mori K. and Ishikawa N.
    Fluorescent X-ray Imaging with Synchrotron Radiation for the Evaluation of Probes for Biomedical Functions: A Pilot Study on 4-Bromo-DL-phenylalanine for Cancer Detection in Mice.
    ASVPI, 12: 67-73, 2007.
  4. Shikano N., Nakajima S., Kotani T., Ogura M., Sagara J., Iwamura Y., Yoshimoto M., Kubota N., Ishikawa N. and Kawai K.
    Transport of D-[1-14C]-Amino Acids into Chinese Hamster Ovary (CHO-K1) Cells: Implications for Use of Labeled D-Amino Acids as Molecular Imaging Agents.
    Nucl. Med. Biol., 34(6): 659-665, 2007.

2007年 総説等

  1. 高村徳人,徳永  仁,帖佐悦男,川井恵一,藤田健一,有森和彦
    薬剤師に必要なタンパク結合置換術
    薬学雑誌, 127(11): 1805-1811, 2007.
  2. 小野口昌久,高山輝彦,川井恵一,森  厚文
    ライフサイエンスのためのアイソトープ測定機器.ライフサイエンスにおけるイメージングV.
    CdTe半導体検出器搭載小型ガンマカメラ:基本性能と実験動物評価
    RADIOISOTOPES, 56(3): 131-139, 2007.
  3. 高村徳人,徳永  仁,帖佐悦男,川井恵一,有森和彦,大井一弥
    薬剤師が“薬術”を獲得することの重要性.—薬学的分布診断法(血清内探索法)と攻めの薬物投与法—
    医薬ジャーナル, 43(3): 963-973, 2007.
  4. 鹿野直人,川井恵一,石川演美
    D-アミノ酸に関する生物学的研究の進展と放射性医薬品の開発
    茨城県立病院医学雑誌, 25(1): 1-9, 2007.

201220112010200920082007200620052004200320022001

ページTOPへ

2006年 著書

  1. 川井恵一,他17名 共著
    「新放射化学・放射性医薬品学」(改訂第2版),佐治英郎・前田 稔・小島周二編集
    第6章 5. オートラジオグラフィー pp.105-110,第10章  6. 放射性医薬品による被ばくと管理pp.286-292,全323頁,南江堂,東京,2006.
  2. 川井恵一
    「放射線関係法規概説 −医療分野も含めて−」
    全編pp.1-193,全193頁,通商産業研究社,東京,2006.

2006年 原著論文

  1. Yoshimoto M., Kinuya S., Kawashima A., Nishii R., Yokoyama K. and Kawai K.
    Radio-iodinated VEGF to Image Tumor Angiogenesis in a LS180 Tumor Xenograft Model.
    Nucl. Med. Biol., 33(8): 963-969, 2006.
  2. Kobayashi M., Okazawa H., Tsuchida T., Kawai K., Fujibayashi Y. and Yonekura Y.
    Diagnosis of Misery Perfusion using Noninvasive 15O Gas PET.
    J. Nucl. Med., 47(10): 1581-1586, 2006.
  3. Matsushita S., Chuang V.T., Kanazawa M., Tanase S., Kawai K., Maruyama T., Suenaga A. and Otagiri M.
    Recombinant Human Serum Albumin Dimer has High Blood Circulation Activity and Low Vascular Permeability in Comparison with Native Human Serum Albumin.
    Pharm. Res., 23(5): 882-891, 2006.
  4. 田原義弘,川井恵一,下新原  茂,久家教幸,田村正三
    放射線・可視光同時撮像ピンホールカメラの開発と透視中散乱線の撮像
    Radioisotopes, 55(5): 247-252, 2006.
  5. Iwao Y., Anraku M., Yamasaki K., Kragh-Hansen U., Kawai K., Maruyama T. and Otagiri M.
    Oxidation of Arg-410 Promotes the Elimination of Human Serum Albumin.
    Biochim. Biophys. Acta, 1764(4): 743-749, 2006.
  6. Shikano N., Nakajima S., Kotani T., Itoh Y., Nishii R., Yoshimoto M., Flores II L.G., Saji H., Ishikawa N. and Kawai K.
    Detection of Maleate-induced Fanconi Syndrome by Decreasing Accumulation of 125I-3-Iodo-α-methyl-L-tyrosine in the Proximal Tubule Segment-1 Region of Renal Cortex in Mice: A Trial of Separate Evaluation of Reabsorption.
    Ann. Nucl. Med., 20(3): 175-181, 2006.
  7. Iwao Y., Anraku M., Hiraike M., Kawai K., Nakajou K., Kai T., Suenaga A. and Otagiri M.
    The Structural and Pharmacokinetic Properties of Oxidized Human Serum Albumin, Advanced Oxidation Protein Products (AOPP).
    Drug Metab. Pharmacokinet., 21(2): 140-146, 2006.

2006年 総説等

  1. 川井恵一吉本光喜
    Post-FDGを目指した新規腫瘍診断用PET製剤の開発動向
    日本放射線技術学会雑誌, 62(6): 764-770, 2006.
  2. 鹿野直人,川井恵一中島修一,小倉正人,小谷高志,相良順一,酒井正春,窪田宜夫,岩村幸雄,石川演美
    18F標識アミノ酸製剤開発の戦略と展望:ポストFDGとして期待されるPET用分子プローブ
    茨城県立病院医学雑誌, 24(3): 93-100, 2006.

201220112010200920082007200620052004200320022001

ページTOPへ

2005年 著書

  1. 川井恵一,他8名 共著
    放射線技術学シリーズ「放射線安全管理学」,日本放射線技術学会監修
    第5章 5・4. 非密封放射性同位元素の使用施設  pp.76-88,全229頁,オーム社,東京,2005.
  2. 飯田博美,安東  醇,川井恵一
    放射線双書「放射線管理学」(改題第4版)
    全編pp.1-193,全193頁,通商産業研究社,東京,2005.

2005年 原著論文

  1. Ishida Y., Kawai K., Magata Y., Abe H., Yoshimoto M., Takeda R., Hashiguchi H., Mukai T. and Saji H.
    Alteration of Striatal [11C]Raclopride and 6-[18F]Fluoro-L-3,4-dihydroxyphenylalanine Uptake Precedes Development of Methamphetamine-induced Rotation Following Unilateral 6-Hydroxydopamine Lesions of Medial Forebrain Bundle in Rats.
    Neurosci. Lett., 389(1): 30-34, 2005.
  2. Tarohda T., Ishida Y., Kawai K., Yamamoto M. and Amano R.
    Regional Distribution of Manganese, Iron, Copper and Zinc in the Brains of 6-Hydroxydopamine-indeced Parkinsonian Rats.
    Anal. Bioanal. Chem., 383(2): 224-234, 2005.
  3. Takamura N., Maruyama T., Chosa E., Kawai K., Tsutsumi Y., Uryu Y., Yamasaki K., Deguchi T. and Otagiri M.
    Bucolome, a Potent Binding Inhibitor for Furosemide, Alters the Pharmacokinetics and Diuretic Effect of Furosemide: Potential for Use of Bucolome to Restore Diuretic Response in Nephrotic Syndrome.
    Drug Metab. Dispos., 33(4): 596-602, 2005.
  4. Yamasaki K., Takamura N., Kuga N., Hidaka M., Iwakiri T., Nishii R., Okumura M., Kodama H., Kawai K. and Arimori K.
    Inhibitory Effects of Amino-acid Fluids on Drug Binding to Site II of Human Serum Albumin in vitro.
    Biol. Pharm. Bull., 28(3): 549-552, 2005.

201220112010200920082007200620052004200320022001

ページTOPへ

2004年 著書

  1. Nishii R., Kawano H., Tani A., Nakamura K., Wakamatsu H., Umemura Y., Ogita M., Fujimoto T., Nagamachi S., Fujita S., Futami S., Kuratsu J., Nakajo M., Tamura S. and Kawai K.
    F-18 FDG PET and C-11 MET PET Findings in Patients with Five Miscellaneous Brain Tumors.
    PET and Molecular Imaging. State of the Art and Future Perspectives, Tamaki N. and Kuge Y. eds., pp.212-216 in total 287 pages, Elsevier, Amsterdam, 2004.

2004年 原著論文

  1. Nagamachi S., Jinnouchi S., Nishii R., Ishida Y., Fujita S., Futami S., Kodama T., Tamura S. and Kawai K.
    Cerebral Blood Flow Abnormalities Induced by Transient Hypothyroidism after Thyroidectomy. —Analysis by Tc-99m-HMPAO and SPM96 —.
    Ann. Nucl. Med., 18(6): 469-477, 2004.
  2. Shikano N., Kawai K., Nakajima S., Kubodera A., Kubota N., Ishikawa N. and Saji H.
    Transcellular Transport of 4-Iodo-L-meta-tyrosine via System L across Monolayers of Kidney Epithelial Cell Line LLC-PK1.
    Nucl. Med. Biol., 31(4): 477-482, 2004.
  3. Shikano N., Kawai K., Nakajima S., Nishii R., Flores II L.G., Kubodera A., Kubota N., Ishikawa N. and Saji H.
    Renal Accumulation and Excretion of Radioiodinated 3-Iodo-α-methyl-L-tyrosine.
    Ann. Nucl. Med., 18(3): 263-270, 2004.
  4. Shikano N., Kawai K., Nakajima S., Kubodera A., Kubota N., Ishikawa N. and Saji H.
    Transcellular Transport of Radioiodinated 3-Iodo-α-methyl-L-tyrosine across Monolayers of Kidney Epithelial Cell Line LLC-PK1.
    Ann. Nucl. Med., 18(3): 227-234, 2004.
  5. Ishida Y., Kawai K., Magata Y., Takeda R., Hashiguchi H., Abe H., Mukai T. and Saji H.
    Changes in Dopamine D2 Receptors and 6-[18F]Fluoro-L-3,4-dihydroxyphenylalanine Uptake in the Brain in 6-Hydroxydopamine Lesioned Rats.
    Neurodegenerative Dis., 1(2-3): 109-112, 2004.
  6. Shikano N., Kanai Y., Kawai K., Ishikawa N. and Endou H.
    Transport of 99mTc-MAG3 via Rat Renal Organic Anion Transporter 1.
    J. Nucl. Med., 45(1): 80-85, 2004.

201220112010200920082007200620052004200320022001

ページTOPへ

2003年 著書

  1. 川井恵一,他17名 共著
    「新放射化学・放射性医薬品学」
    第6章 5. オートラジオグラフィー pp.102-107,第10章 放射線の防護と管理, 6. 放射性医薬品による被ばくと管理 pp.274-279,全307頁,南江堂,東京,2003.
  2. 飯田博美,安東  醇,川井恵一
    放射線双書「放射線管理学」(改題第3版)
    全編pp.1-182,全182頁,通商産業研究社,東京,2005.

2003年 原著論文

  1. Shikano N., Kawai K., Flores II L.G., Nishii R., Kubota N., Ishikawa N. and Kubodera A.
    An Artificial Amino Acid, 4-Iodo-L-meta-tyrosine: Biodistribution and Excretion via Kidney.
    J. Nucl. Med., 44(4): 625-631, 2003.
  2. 田原義弘,川井恵一,中村  貴,後藤稔男,田村正三
    温度による個人被曝線量計の測定値への影響(Ⅱ)—OSL線量計・ガラス線量計—
    Radioisotopes, 52(5): 231-234, 2003.
  3. 長町茂樹,陣之内正史,西井龍一,藤田晴吾,二見繁美,田村正三,川井恵一
    Autoradiography 法を応用した123I-IMP 分割投与によるアセタゾラミド負荷脳循環予備能定量一日法の考案
    核医学, 40(2): 151-162, 2003.
  4. Anraku M., Kragh-Hansen U., Kawai K., Maruyama T., Yamasaki Y., Takakura Y. and Otagiri M.
    Varidation of the Chloramine-T Induced Oxidation of Human Serum Albumin as a Model for Oxidative Damage in vivo.
    Pharm. Res., 20(4): 684-692, 2003.
  5. 田原義弘,川井恵一,西井龍一,後藤稔男,田村正三
    温度による個人被曝線量計の測定値への影響(Ⅰ)—フィルムバッジ—
    Radioisotopes, 52(4): 180-185, 2003.
  6. Nishii R., Kawai K., Flores II L.G., Kataoka H., Jinnouchi S., Nagamachi S., Arano Y. and Tamura S.
    A Novel Radiopharmaceutical for Detection of Malignant Melanoma Based on Melanin Formation: 3-Iodo-4-hydroxyphenyl-L-cystein.
    Nucl. Med. Commun., 24(5): 575-582, 2003.
  7. 高村徳人,帖佐悦男,奥村  学,横田  崇,藤田健一,日高宗明,緒方賢治,山崎啓之,徳永  仁,津田聖一,川井恵一,有森和彦
    関節リウマチ(RA)患者に対する鎮痛薬ナブメトンの効果的な投与法
    医薬ジャーナル, 39(3): 1041-1046, 2003.
  8. Shikano N., Kanai Y., Kawai K., Inatomi J., Kim D.K., Ishikawa N. and Endou H.
    Isoform Selectivity of 3-125I-Iodo-α-methyl-L-tyrosine Membrane Transport in Human L-Type Amino Acid Transporters.
    J. Nucl. Med., 44(2): 244-246, 2003.
  9. Shikano N., Kanai Y., Kawai K., Ishikawa N. and Endou H.
    Characterization of 3-[125I]Iodo-α-methyl-L-tyrosine Transport via Human L-Type Amino Acid Transporter 1.
    Nucl. Med. Biol., 30(1): 31-37, 2003.

201220112010200920082007200620052004200320022001

ページTOPへ

2002年 原著論文

  1. Haruta S., Kawai K., Nishii R., Jinnouchi S., Ogawara K., Higaki K., Tamura S., Arimori K. and Kimura T.
    Prediction of Plasma Concentration-Time Curve of Orally Administered Theophylline Based on a Scintigraphic Monitoring of Gastrointestinal Transit in Human Volunteers.
    Int. J. Pharm., 233(1-2): 179-190, 2002.
  2. Nagamachi S., Jinnouchi S., Kurose T., Nishii R., Kawai K., Futami S., Tamura S. and Matsukura S.
    Serial Change in 123I-MIBG Myocardial Scintigraphy in Non-insulin-dependent Diabetes Mellitus.
    Ann. Nucl. Med., 16(1): 33-38, 2002.

201220112010200920082007200620052004200320022001

ページTOPへ

2001年 著書

  1. Kawai K., Takamura N., Nishii R., Jinnouchi S., Nagamachi S., Tamura S., Arimori K. and Otagiri M.
    Competitive Displacement of Serum Protein Binding to Regulate Pharmacokinetics.
    Proceedings of International Symposium on Serum Albumin and α1-Acid Glycoprotein from Basic Sciences to Clinical Applications, Otagiri M., Sugiyama Y., Testa B. and Tillement J.P. eds., pp.181-192 in total 349 pages, Tokyo Print, Tokyo, 2001.

2001年 原著論文

  1. Nagamachi S., Jinnouchi S., Nabeshima K., Nishii R., Flores II L.G., Kodama T., Kawai K., Tamura S., Yokogami K., Samejima T. and Wakisaka S.
    The Correlation between 99mTc-MIBI Uptake and MIB-1 as a Nuclear Proliferation Marker in Glioma: A Comparative Study with 201Tl.
    Neuroradiology, 43(12): 1023-1030, 2001.
  2. 長町茂樹,陣之内正史,西井龍一,二見繁美,田村正三,松崎泰憲,鬼塚敏男,川井恵一
    孤立性肺結節における201Tl-SPECT の診断能の再検討.—生検、腫瘍マーカー検査との比較—
    核医学, 38(6): 737-745, 2001.
  3. Haruta S., Kawai K., Jinnouchi S., Ogawara K., Higaki K., Tamura S., Arimori K. and Kimura T.
    Evaluation of Absorption Kinetics of Orally Administered Theophylline in Rats Based on Gastrointestinal Transit by Gamma Scintigraphy.
    J. Pharm. Sci., 90(4): 464-473, 2001.